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2018-08-28
The Indonesian Journal Chest & Critical Emergency Medicine   eISSN : 2614-2759   /pISSN : 2355-4584   publishes scholarly journals magazine containing original articles, case reports, and review article in subspecialty areas of respirology, critical illness care and medical emergencies. All journals are available for free download online...

 

TERAKREDITASI DIKTI Surat Keputusan Direktur Jenderal Penguatan Riset dan Pengembangan Kementerian Riset, Teknologi, dan Pendidikan Tinggi Nomor 21/E/KPT/2018, tanggal 09 Juli 2018 tentang PERINGKAT AKREDITASI JURNAL ILMIAH PERIODE I TAHUN 2018

 PERPARI (Perhimpunan Respirologi Indonesia) Dept. of Internal Medicine Division of Respirology and Critical Care Internal Medicine Department of Internal Medicine, Faculty of Medicine University of Indonesia, Dr. Cipto Mangunkusumo National General Hospital Jl. Diponegoro No. 71 Jakarta INDONESIA, Fax: 021-31902461,Phone : +6221 314 9704,  E-mail: ina.j.chest@gmail.com    

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Current Issue

Vol 10 No 2 (2023): COMPARING THE EFFECTIVENESS OF FIXED-DOSE COMBINATIONS AND SEPA­RATE-TABLET REGIMENS ON 2-MONTH PULMONARY TUBERCULOSIS SPUTUM CONVERSION

COMPARING THE EFFECTIVENESS OF FIXED-DOSE COMBINATIONS AND SEPARATE-TABLET REGIMENS ON 2-MONTH PULMONARY TUBERCULOSIS SPUTUM CONVERSION
Ichsan Fauzi Triyoga1, Mira Yuliarti2
1Program Studi Profesi Dokter, Fakultas Kedokteran Universitas Indonesia
2Divisi Pulmonologi, Departemen Gastroenterohepatobilier, Rumah Sakit Umum Pusat Nasional Cipto
Mangunkusumo, Fakultas Kedokteran Universitas Indonesia

ABSTRACT

Background: Tuberculosis (TB) is one of the leading causes of death amongst other non-communicable diseases, accounting for up to 845 thousand cases in 2020 in Indonesia alone. Currently, the WHO recommends the use of anti-tuberculosis fixed dose combinations (FDCs) for treating lung TB. However, before the existence of FDCs, patients rely on the use of anti-TB separate tablets (STs). Both forms offer excellent effectiveness and could be measured objectively through bacterial smear conversion, but different dosages and compliance in each individual may alter the outcomes they offer.
Methods: 5 online databases (Cochrane Central Registers of Trials, Cochrane Database of Systematic Review, Embase Classics, MEDLINE(R) ALL, and Pubmed) were used in finding potential studies. Studies were appraised using the Oxford Center for Evidence-Based Medicine (CEBM) Tool, specifically in the validity, importance, and applicability of the studies.
Result: 24 articles were acquired from literature search, and 3 randomized controlled trials (RCTs) were reviewed. All studies found statistically insignificant results between FDCs and STs in 2-month sputum smear conversion. The negative percentage of patients with a negative 2-month sputum conversion result using FDCs ranges from 88% - 96% and those using STs ranges from 89% - 96%. Relative risk results for all studies are within the 95% CI range, hence precision of results are more certain.
Conclusion: In conclusion, all studies reported FDCs nor STs to have significant effectiveness difference in 2-month sputum smear conversion rate. Future studies should consider doing individual analysis of these forms of anti-TB treatment on bacterial smear conversion with factors that could influence conversion time.
Keywords: fixed dose combinations, separate tablets, 2-month sputum smear conversion, lung tuberculosis

Published: 2023-12-21
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Table of Contents Vol 10 No 1 | Januari-Juni 2023
 

EDITORIAL

Sub-spesialis Konsultan Pulmonologi dan Medik Kritis..................................................................................................................................................................... Gurmeet Singh  

 

ORIGINAL ARTICLE
Prognostic Nutritional Index (PNI) As A Prognostic Factor In Stage Iv Lung Adenocarcinoma........................................................................................................... Subroto , Eko Budiono , Sumardi (PDF) 

Trakeostomi Dilatasional Perkutan Pada Pasien Perawatan Intensif...................................................................................................................................................... Harris Soetanto, Gurmeet Singh (PDF)

 

ARTICLE REVIEW
Gambaran Efek Samping Panduan Standar Jangka Pendek Dan Panjang Pada Tuberkulosis Resisten Obat.......................................................................... Annisa Nurfaujiah, Ferdy Ferdian, Basti Andriyoko (PDF)

The Role of Chronic Inflammation in the Development of Depression in COPD Patients...... Vania Tryanni, Hamzah Shatri, Dika Sinulingga, Vinandia Irvianita, Edward Faisal, Rudi Putranto, Gurmeet Singh, Ceva W. Pitoyo (PDF)


Perkembangan Precision Medicine di Indonesia........................................................................................................................................................... Telly Kamelia, Nurul Amelia Rahayu Putri (PDF)

 

CASE REPORT
Pneumonectomy in Congenital Lobar Emphysema................................................................. Susan Hendriarini Mety, I Putu Kokohana Arisutawan, Muhammad Aris Furqon (PDF)


Difficulty in Controlling Malignant Pleural Effusion................................................................................................................................................................ Ignatius B Prasetya, Eric D Tenda (PDF)


Acute Digitalis Toxicity presenting as Bradycardia in patient with Atrial Fibrillation with Heart Failure ........................................................................................ RaymondPranata,Emir Yonas, Veresa Chintya (PDF)


A Case of Spontaneous Hemorrhagic Transformation in a patient with Cardioembolic Stroke due to Atrial Fibrillation..................................................................... Raymond Pranata, Veresa Chintya, Emir Yonas (PDF)

 

ADDED ARTICLE

Studi Kualitatif Risiko Keselamatan Dan Kesehatan Kerja Dengan Metode Job Safety Analysis Pada Tenaga Perawat   

Dampak Keterlambatan Pengembalian Rekam Medis Pasien Rawat Inap Terhadap Pelaporan Rumah Sakit Dan Pengajuan Klaim BPJS Kesehatan Di Rumah Sakit Umum Ganesha Kabupaten Gianyar

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