Muhammad Ranushar, Harun Iskandar, Nur Ahmad Tabri, Makbul Aman, Syakib Bakri
Departement of Internal Medicine Medical Faculty
Hasanuddin University Makassar
ABSTRACT
Background: Asthma is an important chronic airway disease and is still a serious and mass public
health problem in many countries. Asthma control has been difficult to achieve using conventional
therapies such as short-acting beta 2 agonist (SABAs), oral beta 2 agonists, oral corticosteroids
and theophylline, leading to asthma difficult to control. Treatment of asthma based on GINA uses
asthma control medications (controller) in the form of inhalation of beta 2 agonist combination
with inhaled steroid/Inhaled Corticosteroid (ICS) and can be a combination of both. Classification
of degree control based on GINA is considered more practical, easier to adapt, and more clinically
valuable.
Objective: To know the relationship of type therapy with degree of control and lung function of
asthma patient.
Methods: This study was a cross-sectional study. The samples used were patients with asthma
diagnosis both outpatient and inpatient according to GINA criteria. The subjects of the study were
data collection in the form of therapy method. Spirometry measurements determine FEV1% and
asthma control degree according to GINA criteria. The study was conducted in February-May
2016 at Pulmonology Polyclinic RS Wahidin Sudirohusodo Makassar and Hasanuddin University
hospital in Makassar
Results: The age of the subjects varied between 19 and 69 years old, the FEV1% score ranged from
18% to 98%, male subjects were 23 (33,8%) and 45 (66,2%). There was no significant association
of therapeutic method with lung function (p> 0,05). There is a significant relationship between
therapy method and degree of control asthma (p <0,001).
Conclusions: In patients with asthma who received combination therapy such as combination
budesonide and formoterol or salmeterol and fluticasone significantly more achieved a better
degree of control than in patients who only received agonist beta 2 inhalation or corticosteroid
inhalation only.
Keywords: Asthma, therapeutic method, lung function, a degree of control, Forced Expiration
Volume 1, Inhalation of beta 2 agonists, inhaled corticosteroids, inhalation corticosteroid and beta-
2 agonist combination.