I Wayan Hero Wantara1, Ceva Wicaksono Pitoyo1, Andhika Rachman2, Cleopas Martin Rumende1
1Respirology and Critcal Illness Division, Internal Medicine Departement, Faculty of Medicine Indonesia University, Cipto Mangunkusumo National General Hospital, Indonesia.
2Medical Hematology-Onkology Division, Internal Medicine Departement, Faculty of Medicine Indonesia University, Cipto Mangunkusumo National General Hospital, Indonesia.
Introduction: Lung cancer patients often experience pneumonia. This is due to the decrease in body endurance of the patients. Pneumonia complicates treatment, worsens the quality of life, reduces survival, and is often a direct cause of death for lung cancer patients. Dealing with pneumonia in non- small cell lung cancer (NSCLC) patients with continuous antimicrobials treatment without regard to culture sensitivity will cause resistance of germs that cause pneumonia.
Objectives: This study aims to study the characteristics of NSCLC patients, the pattern of germs that cause pneumonia in NSCLC patients, and to compare the survival of NSCLC patients suffering from pneumonia caused by MDR (multidrug resistance) bacteria with those caused by non-MDR bacteria.
Methods: This study was a retrospective cohort with research subjects was NSCLC patients with pneumonia caused by MDR and non-MDR bacteria who were treated at Dr. Cipto Mangunkusumo Hospital from January 2013 to December 2017. Analysis was performed with multivariate cox regression analysis.
Results: The results 32 subjects were infected only from MDR bacteria, 14 subjects infected by both MDR and non MDR bacteria, and 23 subjects were infected by only non-MDR bacteria. The most non-MDR bacteria that cause pneumonia in NSCLC patients was Klebsiella pneumoniae as much as 37,3%, while the most MDR bacteria that cause pneumonia in NSCLC patients was Acinetobacter baumannii as much as 23,2%. Median survival of NSCLC patients with pneumonia caused by MDR bacteria was 57 days (43,707-70,293) while those by non-MDR bacteria was 92 days (58,772-125,228).
Conclusions: The survival of NSCLC patients with pneumonia caused by MDR bacteria is shorter than that caused by non-MDR bacteria.
Key words: MDR, NSCLC, Pneumonia, Survival
