Giri Satriya1, Gurmeet Singh2, Rudi Putranto3, Hamzah Shatri4
1Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Indonesia-RSUPN Cipto Mangunkusumo
2Divisi Respirologi dan Penyakit Kritis, Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Indonesia-RSUPN Cipto Mangunkusumo
3Divisi Psikosomatik dan Paliatif, Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Indonesia-RSUPN Cipto Mangunkusumo
4Unit Epidemiologi Klinik Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Indonesia-
RSUPN Cipto Mangunkusumo
Abstract
Background: Dispnea as a subjective sensation is a sign of certain underlying disease which need to be diagnosed and treated to prevent the mortality, especially in patients with progressive disease. Previous study has shown that patients with dyspnea at admission have higher mortality.
Objective: To determine the association between dyspnea with 1 year survival in patients with progressive disease who were admitted to RSCM. Methods: A retrospective cohort study was conducted by tracing the medical records of 155 patients with progressive disease who were hospitalized at RSCM during August 2018 until December 2019. Recruited subjects were adults patients who 18 years above diagnosed with COPD, heart failure, malignancy or CVD. Identity, dispnea, and survival data were collected through medical records. Statistical analysis was conducted by using multivariate and Kaplan Meier analysis using SPSS software. Results: In this study, the survival rate of patients with progressive disease who were admitted to RSCM in August 2018-December 2019 was 34.8% with a mean survival of 163 days and a median survival of 72 days. Among the patients 49% had dyspnea. The survival rate of patients with dispnea was 11% with a mean survival of 115 days and a median survival of 29 days. Dyspnea was significantly associated with survival with p < 0,05 and adjusted HR 1.928 (95% CI: 1.225 - 3.03). In the subgroup analysis of heart failure, malignancy, and CVD, dispnea was associated with survival with p<0,05 and the HR value for every group 16,59 (95% CI: 2,20 – 124,73), 2,18 (95% CI: 1,33 – 3,58), and 2,90 (95% CI: 1,34 – 6,28). Conclusion: Dyspnea has significant association with survival.
Key words: dyspnea, progressive disease, survival.
