The Role of Chronic Inflammation in the Development of Depression in COPD Patients

Vania Tryanni 1 , Hamzah Shatri1,3, Dika Sinulingga1, Vinandia Irvianita1, Edward Faisal1, Rudi Putranto1, Gurmeet Singh2, Ceva W. Pitoyo2
1 Psychosomatic and Palliative Division, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
2 Respirology and Critical Care Division, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia
3 Clinical Epidemiology in Department of Internal Medicine, Faculty of Medicine Universitas Indonesia- Cipto Mangunkusumo Hospital, Jakarta, Indonesia

ABSTRACT

COPD is one of the most prevalent disease and the prevalence is still increasing. Depression is one of the most prevalent comorbid found in COPD and associated with increase mortality and reduced quality of life. The linked between booth of them can’t be fully elucidated. One of the theories is chronic inflammation. Increase inflammatory state is associated development of depression to some pathway, and there is direct link between serotonin-inflammation. COPD is a well-known inflammatory state with same increasing inflammatory state. There are also similar characteristics between depression with inflammatory stated and depression in COPD such as atypical symptom and resistance to therapy. Studies also proved that there were increase in cytokine especially IL-6 , IL-2 and IFN gamma in COPD -Depression.
Keyword: COPD, Depression, Chronic Inflammation