Elcia Melisa Dwisari Simatupang1*, Fransiscus Ginting2,
Elvando Tunggul Mauliate Simatupang3
1Public Health Center of Uluan Sub-District, Government of Toba District, Province of North Sumatera
2Department of Internal Medicine, Haji Adam Malik Central General Hospital, Medan,
Province of North Sumatera
3Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Riau University, Pekanbaru, Province of Riau

ABSTRACT
Diabetes mellitus (DM) is a challenge in controlling Pulmonary Tuberculosis (PTB) cases. The increase in DM cases is one of the reasons that Indonesia is the second highest contributor of PTB cases in the world. The relationship between these two diseases impacts morbidity and mortality globally. This condition is based on the role of each individual’s immune system against Mycobacterium tuberculosis (Mtb) infection. Impairment of the innate and adaptive immune system in eliminating Mtb infection influences the increase of PTB cases with DM. Early prevention is important in the interaction of DM and PTB.
Keywords: Diabetes Mellitus, Tuberculosis,
Interaction, Risk Population