Cardiovascular disease is the leading global cause of death, accounting for 17,3 million deaths per year, a number that is expected to grow to more than 23.6 million by 2030.1Of these deaths, an estimated 7,3 million were due to CAD.2Inflammation plays an integral role in the pathogenesis of atherosclerotic CAD.3-5 Therefore the interest in the EAT that is located between the myocardium and the pericardium surrounding both ventricles with variable extent and distribution patterns arouse.6-8 Because of its endocrine and paracrine activity, secreting pro-inflammatory and anti-inflammatory cytokines and chemokines, it has been suggested to influence coronary atherosclerosis development.9-13 TTE enables non-invasive assessment of EAT.14,15To date, the correlation of EAT with severity of CAD in Indonesia remains unknown. To address this issue, we examined the relationship between EAT thickness measured by TTE with coronary lesion severity in Indonesian patients with stable CAD. Methods Study Design The study was designed as an observational cross-sectional study. It was approved by Hasanuddin University ethic committee and written informed consent was obtained from all participants.