Background: The severity of tuberculosis (TB) disease and its appropriate treatment is determined by bacillary load, extent of disease and anatomical site. A case of pulmonary TB is classified as severe when parenchymal involvement is extensive or miliary disseminated. Meanwhile, extra-pulmonary TB is classified as severe when it manifests as meningeal, pericardial, peritoneal, bilateral or extensive pleural effusion, spinal, intestinal and genitourinary TB. Severe TB patients have higher risk of death.
Objective: To assess the profile of hospitalized severe TB patients in Cipto Mangunkusumo Hospital, Jakarta.
Methods: A descriptive study was performed on hospitalized severe TB patients in Cipto Mangunkusumo Hospital between January 2008-September 2013. Data of inpatients at admission and in-hospital mortality status were assessed.
Results: A total of 78 patients were evaluated. In-hospital mortality rate was 34,6%. There were 52 (66.7%) male and median age of the sample was 30 (range 18-80) years old. Miliary TB was found in 40 (51,3%) subjects, whereas meningeal TB was found in 38 (48,7%) subjects. A major part (65,8%) of the patients were malnourished with BMI <18,5 kg/m2. Fifty percent subjects were HIV-positive. Chronic liver disease was the most common comorbidity (20,5%).
Conclusion: Most hospitalized severe TB patients in Cipto Mangunkusumo Hospital were male at 18-80 years old. Most of the patients had military TB. Most of the patients were malnourished. Chronic liver disease was the most common comorbidity. In-hospital mortality rate was high.
Key words: In-hospital mortality, profile, severe tuberculosis.