Irawan F Kusuma1, Ika Trisnawati2, Eko Budiono2
1Departemen Ilmu Penyakit Dalam FK UGM/RS Dr. Sardjito Yogyakarta
2Divisi Pulmonologi Departemen Ilmu Penyakit Dalam FK UGM /RS Dr. Sardjito Yogyakarta

ABSTRACT
Background: ARDS is a critical disease that has a mortality rate of 40-60%. Mortality due to ARDS is influenced by some factors that can be predicted. Those factors should be taken into consideration in patient management so that the mortality rate can be reduced.
Objective: To observe factors that have high contribution to the mortality due to ARDS and to give recommendation based on those factors.
Methods: This is a cross sectional study. Research subjects are ARDS patients admitted to Intensive Care Unit Sardjito Hospital, Yogyakarta from January 2009 till December 2014. ARDS diagnosis was defined based on AECC criteria. Demographic data, laboratory results, and its follow up were obtained from medical records. Data were analyzed using SPSS 17. Bivariate and multivariate analysis with log regression were used to determine the contribution of related factors to mortality.
Results: There are a total of 101 subjects (72 patients are dead and 29 patients are alive) in study. Bivariate analysis showed that there are six factors affecting mortality: pneumonia, COPD, MODS, leucocyte count, pleural effusion, and vasopressor use. According to multivariate analysis, all factors have significant contribution to mortality, except pleural effusion. Factor with the highest odds ratio value are pneumonia (6.4) and the lowest are vasopressor use (4.9).
Conclusion: There are five factors with significant contribution to mortality of ARDS patients admitted to ICU. Those factors are pneumonia, COPD, leucocyte count, MODS, and the use of vasopresor. Therefore, it is very important to give more attention to those factors and to give optimal therapy based on those factors in managing patients with ARDS to reduce its mortality.
Key words: mortality, ARDS, ICU.