Gurmeet Singh1, Ceva Wicaksono Pitoyo1, Dita Aditianingsih2, Cleopas Martin Rumende1
1 Departemen Ilmu Penyakit Dalam, Divisi Respirologi dan Penyakit Kritis, Universitas Indonesia, Rumah Sakit Ciptomangunkusumo, Jakarta
2 Departemen Anestesi dan Perawatan Kritis, Universitas Indonesia, Rumah Sakit Ciptomangunkusumo, Jakarta

ABSTRACT
Background: The incidence of Invasive Fungal Disease (IFD) is increasing worldwide in the past 2 to 3 decades. Critically ill patients in Intensive Care Units (ICU) are more vulnerable to fungal infection. Early detection and treatment are important to decrease morbidity and mortality in critically ill patients.
Objective: To profile critically ill patient associated with early invasive fungal disease.
Method: Prospective cohort study was conducted on critically ill patients at Cipto Mangunkusumo Hospital within March 2015 - September 2015 period. Total number of subject (74) in this study was drawn based on one of the risk factor (HIV). Specimens were collected on day 5 to 7 of hospitalization.
Results: A total of 206 patients were enrolled in this study. Among 74 subjects with IFD, majority were males (52.7%), mean age was 58 years (range 18-79), mean Leon’s Scores was 3 (score range 2-5), majority group was non-surgical/ non- trauma patient (72.9%), and mean fungal isolation was positive on the 5th day. The highest number of isolated fungal specimen found in this study was Candida sp (92.2%). Urine culture yields the highest fungal isolates (70.1%). Mortality rate in this study was 50%.
Conclusion: Incidence of early invasive fungal disease mostly found in critically ill patients with high mortality rate.

Key words: Critically ill, invasive fungal disease.